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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can cut down panobinostat stages by ~70% and result in procedure failure.pentobarbital will reduce the level or outcome of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Import